More on VITILOGO

Vitiligo - is the most common chromatosis, 3-4% of people with skin diseases.


Frequency in the population is 0,14-8,8%. Can occur at any age in both sexes and all races. In 25% of cases for the first time begins at the age of 12, 50% - up to 20 years.

Vitiligo white patches appears on different parts of the skin. The disease is often seen as a cosmetic defect, but the evidence of irregularities of the body as a whole system.

Degree and rate of development of the process of depigmentation usually depend on compensation related chronic diseases of the gastrointestinal tract, liver, neurosis and pathology of endocrine glands. In the latter case, the most frequently observed dysfunction of the thyroid gland and the adrenal cortex.

The appearance of white spots due to the destruction of melanocytes, cells located in the basal layer of the skin, with numerous processes.

Education skin coloring agent melanin - a complex biochemical process. It begins with the hydroxylation of essential amino acid phenylalanine to tyrosine, which is activated by the action of tyrosinase by copper ions is oxidized to dihydroxyphenylalanine and then dioksidenilalaninhinon.

As a result of spontaneous oxidation last turns into melanin. Melanin is the melanocytes, which are unicellular glands. From melanocytes are distributed pigment in keratinocytes, moving it to the outer layers of the epidermis, where it has a protective function

from harmful solar radiation and irradiation.

Vitiligo occurs when the destruction of melanocytes not only in the lesion, but also in the surrounding intact skin.

Currently, there are three main hypotheses to explain the development of vitiligo - neural, and autoimmune augodestruktivnaya.

According to the neural hypothesis, high concentrations of neurochemical substances (acetylcholine,

norepinephrine, epinephrine) around the pigment cells reduces the production of melatonin.

The content of acetylcholine in the skin regulates enzyme cholinesterase. With age, the level around

hair follicles is reduced, which leads to an increase in local concentrations of ACh, causing graying hair. By analogy allows for the loss of skin pigment at lower cholinesterase in the microenvironment of pigment cells.

In the occurrence of vitiligo is important, some authors give the neuro-psychological, psycho-emotional factors, stressful situations. A role in this case have metabolic catecholamines. With nervous excitement norepinephrine and other mediators released from nerve endings involved in the destruction of melanocytes. Catecholamine levels in the urine of patients with vitiligo increased. They have a direct cytotoxic effect on melanocytes due to the presence in their structure of the phenolic ring. These

substances are readily oxidized to form toxic radicals. In the skin and mucosal vasoconstriction occurs, leading to hypoxia of the skin and the accumulation of free radicals.

Augodestruktivnaya hypothesis in the origin of vitiligo basic knowledge ¬ chenie gives phenol and its derivatives, which have a cytotoxic effect on pigment cells. Substances with an aromatic or aliphatic chains can cause depigmentation of the skin. Vitiligo is common among workers employed in the manufacture of rubber and plastic products, household chemicals, with various contacts with phenol

and its derivatives. Supposed hereditary sensitivity to phenols.

According to the autoimmune theory, vitiligo considered an autoimmune disease. The basis for this are due to a number of immune disorders - tireiodit Hashimoto, diabetes, thyrotoxicosis, Down syndrome, disgammaglobulinemiya, autoimmune hemolytic anemia, adrenal insufficiency. Attempts to identify antimelanotsitarnye antibodies and cytotoxic lymphocytes were unsuccessful, have been identified as any immunootvetstvennyh genes. Some authors have noted in patients with vitiligo high activity of natural killer cells, with normal T and B lymphocytes. When duration of the disease over 5 years null cells are involved in the process of destruction of melanocytes, although the effect of killer

not specified.

In the pathogenesis of the disease has a significant role the endocrine system, especially the function of the thyroid gland. In some cases, after surgical skin pigmentation is restored.

Uncertainty of the etiology and pathogenesis of insufficient knowledge, persistent chronic disease, susceptibility to the spread of the process cause difficulties in treating vitiligo.

To date there are no radical chemotherapy reducing skin pigmentation. Traditionally appointed agents copper, B vitamins, benzonal, FHG and others do not give the severity of clinical outcome, and the side effects of medication stops the doctor from any destination

therapy, because can lead to iatrogenic diseases.

Diet sheet for fitness

Those who want fat miss from their body, they must have take low carbohydrate food. Follow bellow tips for better results.

Breakfast: Chapati (roti) - Omelet or Milk, Cheese slices, Jam, Peanut Butter and vermicelli-Boiled egg (white)

Lunch: Roti with Chicken, Fish, Egg, Vegetable Curry with less oil, sprouts, Veg. Sandwich, onion salad

What is Bariatric Surgery?

Gastrointestinal surgery for obesity, also called bariatric as surgery , this alters the digestive process so that patients lose their weight safely and effectively. 

There are three types of  laparoscopic bariatric surgical options now a days famous hospitals are offering.

ie. stay in hospital short period and a faster return to work and activity.

1.Gastric Banding: Gastric Banding is a restrictive operation in witch a band is placed around the upper portion of the stomach to decrease the amount of food the stomach can physically hold. it does not interfere with the normal digestive process. Weight loss achieved by decreased food intake. Currently requires one night stay in hospital

ROLE OF NONI IN LEUCODERMA (VITILIGO)

Leucoderma (Vitiligo) is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin; the mucous membranes (tissues that line the inside of the mouth and nose and genital and rectal areas) are destroyed. As a result, white patches of skin appear on different parts of the body. The hair that grows in areas affected by Vitiligo usually turns white.

The cause of Vitiligo is not known, but doctors and researchers have several different theories. One theory is that people develop antibodies that destroy the melanocytes in their own bodies. Another theory is that melanocytes destroy themselves. Finally, some people have reported that a single event such as sunburn or emotional distress triggered Vitiligo; however, these events have not been scientifically proven to cause Vitiligo.

Vitiligo seems to be more common in people with certain autoimmune diseases (diseases in which a person's immune system reacts against the body's own organs or tissues). These autoimmune diseases include hyperthyroidism (an overactive thyroid gland), adrenocortical insufficiency (the adrenal gland does not produce enough of the hormone called corticosteroid), alopecia areata (patches of baldness), and pernicious anemia (a low level of red blood cells caused by failure of the body to absorb vitamin B-12). However, most people with Vitiligo have no other autoimmune disease. Vitiligo may also be hereditary, that is, it can run in families. Children whose parents have the disorder are more likely to develop Vitiligo. However, most children will not get Vitiligo even if a parent has it, and most people with Vitiligo do not have a family history of the disorder.

ROLE OF NONI IN EPILEPSY

Epilepsy is a neurological condition that makes people susceptible to seizures. A seizure is a change in sensation, awareness, or behavior brought about by a brief electrical disturbance in the brain. Seizures vary from a momentary disruption of the senses, to short periods of unconsciousness or staring spells, to convulsions. Some people have just one type of seizure. Others have more than one type. Although they look different, all seizures are caused by the same thing: a sudden change in how the cells of the brain send electrical signals to each other.

If you have epilepsy, you probably already know that it's not a mental disorder. It can be caused by anything that affects the brain, including tumors and strokes. Sometimes epilepsy is inherited. Often, no cause can be found.

ROLE OF NONI IN KIDNEY DISEASES

 Chronic renal failure (CRF) is the progressive loss of kidney function. The kidneys attempt to compensate for renal damage by hyper filtration (excessive straining of the blood) within the remaining functional nephrons (filtering units that consist of a glomerulus and corresponding tubule). Over time, hyper filtration causes further loss of function.

Chronic loss of function causes generalized wasting (shrinking in size) and progressive scarring within all parts of the kidneys. In time, overall scarring obscures the site of the initial damage. Yet, it is not until over 70% of the normal combined function of both kidneys is lost that most patients begin to experience symptoms of kidney failure.

How coffee works as anti canser?

As per the study of Harvard University  drinking six cups of coffee in a day  is very beneficial health. As per result of study the risk of cancer in men prostate gland, women have a uterus problem is supposed to go down it. The researchers explained in their study on 1,17,000 people. Coffee by affecting insulin levels are explained in the study of anti cancer  works.